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. 2019 Jul 2;10:1491. doi: 10.3389/fimmu.2019.01491

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Copyright © 2019 Jia, Gong, Zhao, Yang, Ji, Luan, Zang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ALA on apoptosis in the heart, kidney and small intestine kidney of CLP-induced septic rats. CLP induced markedly increased TUNEL-positive cells in heart, kidney and small intestine. ALA reduced the apoptotic cells in these organs, 3-MA partly reversed this effect of ALA. (A) TUNEL staining of the three organs. (B) Quantitative analysis of the percentage of TUNEL-positive cells. Scale bar: 50 μm. Data are expressed as the mean ± SD, n = 8. **P < 0.01 vs. sham-operated rats; ^##P < 0.01 vs. CLP-operated rats, ^†P < 0.05 vs. ALA-treated CLP rats, ^††P < 0.01 vs. ALA-treated CLP rats.