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. 2019 Jul 8;38:293. doi: 10.1186/s13046-019-1303-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Up-regulation of STAT3 and MTOR expression in CRC tissues and synergism of flubendazole with 5-fluorouracil. (a) The protein expression of STAT3 and mTOR in each of the paired CRC tissue samples (T) and adjacent normal tissue samples (N) obtained from the same patients. (b) HCT116 cells were treated with serial dilutions of flubendazole (Flu), 5-fluorouracil (5-Fu) or the combination of flubendazole plus 5-fluorouracil. Cell viability was measured after 48 h of treatment by the MTT assay. Survival rates were plotted using the GraphPad Prism software. CompySyn was used for determining the combination index. (c) The RKO cells were treated with serial dilutions of flubendazole, 5-fluorouracil or the combination. (d) The SW480 cells were treated with serial dilutions of flubendazole, 5-fluorouracil or the combination. (e) Representative images of the colony-formation assay with DMSO, 5-fluorouracil (20 μM), flubendazole (0.3 μM), or the combination are presented in HCT116 cell, (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)