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. 2019 Jul 2;10:1511. doi: 10.3389/fimmu.2019.01511

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Copyright © 2019 Arioz, Tastan, Tarakcioglu, Tufekci, Olcum, Ersoy, Bagriyanik, Genc and Genc.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 and SIRT1 pathways are co-modulate melatonin effects. N9 microglial cells were treated with melatonin (500 μM) for 1 h. (A) siRNA-mediated Nrf2 knockdown significantly decreased SIRT1 expression N9 microglial cells. (B,C) Inhibition of Nrf2 reversed the melatonin's effect on SIRT1 protein expression. (D,E) siRNA-mediated SIRT1 knockdown significantly decreased Nrf2 translocation. (F) Inhibition of SIRT1 significantly downregulated Nrf2 target genes expression. Data are presented as mean ± S.E.M, n = 5. *p < 0.05, **p < 0.01 compared to control.