Fig. 2.

Representation of the effects of gonadotoxic treatment on the ovary. Illustration of the key effects of cancer treatment on the ovary, highlighting the variable recovery after treatment such that some patients will have permanent premature ovarian insufficiency with infertility and estrogen deficiency, but others will show recovery allowing fertility, although their reproductive lifespan may be shortened. AMH, anti-Müllerian hormone. Reprinted with permission of Taylor and Francis Journals and adapted from Jayasinghe et al. [14].