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. 2019 Jul 9;20:565. doi: 10.1186/s12864-019-5918-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Domain organization of EBPs in Clostridiales. a The domain architecture of EBPs. PAS, Per-Arnt-Sim domain; GAF, cyclic GMP-specific phosphodiesterases, adenylyl cyclases and FhlA; PTS-HPr, PTS system histidine phosphocarrier protein HPr-like; PrpR_N, N-terminal domain of Propionate catabolism activator; ACT, aspartokinase-chorismate mutase-TyrA; CBS, cystathinoine β-synthase domain; Fer4, 4Fe-4S binding domain; Fe_hyd_lg_C, iron only hydrogenase large subunit, C-terminal domain; FeS, Fe-S cluster; V4R, vinyl 4 reductase domain; RR, response regulator domain. b Distribution of TCS and OCS-type EBPs in Enterobacteriales and Clostridiales. c Distribution of PAS-containing EBPs in 23 genera of Clostridiales