Table 1.

Topicals agents used for striae distensae

Topical agent used	Mechanism of action
Tretinoin or retinoic acid	Increase tissue collagen I levels through fibroblastic stimulation
Hyaluronic acid	Increase tensile resistance to mechanical forces
Trofolastin (Centella asiatica)	Stimulation of fibroblasts and antagonist to glucocorticoid effect
Silicone	Skin hydration
Acid peels - glycolic acid, trichloroaceticacid (TCA)	Proliferation of fibroblast and stimulate collagen production by fibroblasts
Ascorbic acid	Improved collagen production
Alphasria	Increasing volume to oppose mechanical atrophy
Cocoa butter	Mositurisation
Oils - olive oil, almond oil, coconut oil, bio oil	Action by massage and cutaneous hydration
Pirfenidone	Immunomodulatory, anti-inflammatory, promote collagenase, fibroblastic activity