Table 3. . Measure of full covariate model performance: development, validation, total cohort and sensitivity analysis.

Model	n	Percentage of population	Hosmer–Lemeshow goodness-of-fit statistics†	Area under the receiver operator curve ‘C-statistic’
			X2, df, p-value
Development	12,738	60%	10.98, 8, p = 0.20	0.784
Validation	8492	40%	10.44, 8, p = 0.24	0.755
Total cohort	21,230	100%	7.78, 8, p = 0.46	0.772
SASI score total cohort	21,230	100%	7.65, 8, p = 0.47	0.769
Sensitivity NIHSS model‡	327	100% IMS III	7.75, 8, p = 0.46	0.854
Sensitivity SASI score model‡	327	100% IMS III	8.30, 8, p = 0.40	0.834

^†performed on a random sample of 1000 observations.

^‡Model controlled for age, treatment group allocation and stroke severity (using either NIHSS or SASI as indicated).

IMS III: International Management of Stroke III; NIHSS: NIH Stroke Scale; SASI: Stroke Administrative Severity Index.