Figure 6. . The application of functional metal-organic framework nanocompositions for theranostics.

(A) Illustration of pH-responsive FCZ nanoparticles as drug delivery vehicles. (B) Subcellular localization of the FCZ nanoparticles by transfected HeLa cells with mecherry-LAMP-1. (C) T₂*-weighted images of A549 cells with FCZ nanoparticles untreated and treated at different concentrations. (D) In vivo antitumor efficacy of DOX-loaded FCZ nanoparticles in the A549 lung cancer mice model tumor. (E) Scheme of the synthesis of DOX-loaded Fe₃O₄@UiO-66 core–shell nanoparticles for imaging and therapy. (F) T₂-weighted MRI images and transverse relativity of Fe₃O₄@UiO-66 at different Fe concentrations. (G) Tumor biopsies from the PBS and Fe₃O₄@UiO-66-DOX-treated mice on day 30. (H) MRI images of HeLa tumor-bearing mice treated by PBS and Fe₃O₄@UiO-66-DOX at different times. (I) Transmission electron microscopy image of the core–shell AuNR@ZIF-8 nanostructures, bottom: HAADF-STEM image and energy-dispersive X-ray spectroscopy elemental mapping of single AuNR@ZIF-8 core–shell nanoparticle. (J) DOX release profiles from the AuNR@ZIF-8-DOX nanostructures with and without 808-nm laser irradiation (1 w/cm²) at different pH values. (K) Relative tumor volume from 4T1 tumor-bearing mice with different types of treatments.

DOX: Doxorubicin; FCZ: Fe3O4@C@ZIF-8; PBS: Phosphate-buffered saline; TEM: Transmission electron microscopy; UiO: Universitetet i Oslo; ZIF-8: Zeolitic imidazolate framework-8.

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