Figure 7. . The porphyrinic metal-organic frameworks for photodynamic therapy.

(A) Transmission electron microscopy image of DBP-UiO MOFs nanoplate. (B) Singlet-oxygen generation from DBP-UiO MOFs, H₂DBP and H₂DBP+HfCl₄. (C) Tumor growth curve of the photodynamic therapy treatment on SQ20B tumor-bearing mice (black and red arrows refer to the injection and irradiation time points). (D) 3D nanoporous structure of the PCN-224 MOFs.  (E) Cellular uptake of different size PCN-224 MOFs nanoparticles at various concentrations (incubation 24 h). (F) In vitro PDT efficacy of PCN-224 MOFs nanoparticles (with and without folic acid functionalization) cultured HeLa cells. (G) Scheme of phosphate-terminal DNA aptamer conjugated Zr-MOFs nanoparticle quencher. (H) Cell viability tests of HeLa cells were cultured with Zr-MOF-library or Zr-MOF-aptamer nanoparticles and irradiated with 650-nm laser light for 5 min (200 mW/cm²), for Zr-MOF-aptamer only, the HeLa cells were cultured Zr-MOF-aptamer nanoparticles without laser irradiation.

DBP: Di(p-benzoato)porphyrin; MOF: Metal-organic framework; PCN: Porous coordination network; UiO: Universitetet i Oslo.

(A) Reproduced with permission from [99] © American Chemical Society licensed with Standard ACS Author Choice/Editors' Choice usage agreement (2014).

(B) Reproduced with permission from [99] © American Chemical Society licensed with Standard ACS Author Choice/Editors' Choice usage agreement (2014).

(C) Reproduced with permission from [99] © American Chemical Society licensed with Standard ACS Author Choice/Editors' Choice usage agreement (2014).

(D) Reproduced with permission from [102] © American Chemical Society (2016).

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(F) Reproduced with permission from [102] © American Chemical Society (2016).

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