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. 2019 Jul 2;10:1466. doi: 10.3389/fmicb.2019.01466

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Copyright © 2019 Qu, Chen, Tian, Wang, Wang, Wang, Li, Ji, Xi, Feng, Tian and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pro-inflammatory cytokines IL-17, IL-22, and TNF-α detected in mouse vaginal tissue. (A,B) Shows elevation of IL-17 concentration detected by ELISA in both the prevention and treatment groups. ^* means p < 0.05, ^∗∗∗ means p < 0.001, compared with the WT group, ^# means p < 0.05, ^### means p < 0.001 compared with the Ca group. (C,D) Elevation of IL-22 concentration detected by ELISA in the prevention and treatment groups. ^∗∗ means p < 0.01, ^∗∗∗ means p < 0.001, compared with the WT group, ^## means p < 0.01, ^### means p < 0.001 compared with the Ca group. (E,F) Elevation of TNF-α concentration detected by ELISA in both the prevention and treatment groups. ^∗∗ means p < 0.01, ^∗∗∗ means p < 0.001 compared with the WT group, ^## means p < 0.01, ^### means p < 0.001 compared with the Ca group.