Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 2;10:1485. doi: 10.3389/fmicb.2019.01485

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Sharma, Rodionov, Leyn, Tran, Iablokov, Ding, Peterson, Osterman and Peterson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

In vivo experimental design. (A) Humanization of germ free mice was carried out by successive gavage with human feces derived from 5 healthy human subjects (HF) at 1 week intervals. After the final gavage, mice were maintained for 4 weeks and fecal pellets from humanized mice (HM) were collected. Lower panel. Germ free mice were gavaged twice with fecal pellets derived from humanized mice at an interval of 2 days. Fecal pellets were collected on Day 7 (controls). B-vitamin supplementation in drinking water (Table 1) was maintained for 4 weeks and fecal pellets were collected for 16S rRNA sequencing and cecal contents were collected for LC/MS measurement of B-vitamins. (B) PCoA analysis of mouse humanization. Unweighted Uni-Frac β-diversity of communities at different stages of humanization.