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Effect of GABAB Antagonist Saclofen on Artemisinin Antinociception in the Acetic Acid-Induced Writhing Test in Mice (n =6)
| Treatment | Dose (mg/kg, i.p.) | Writhing count (mean ± SEM) | Inhibition (%) |
|---|---|---|---|
| Artemisinin | 10 | 32.17 ± 2.14 | 63.08 |
| Saclofen | 2 | 71.45 ± 8.05* | 0* |
| Saclofen + artemisinin | 2 + 10 | 34.29 ± 5.11 | 57.27 |
i.p.: intraperitoneal, SEM: standard error of mean.
P < 0.0001 vs. artemisinin.
