Figure 7.
Effects of non-absorbable broad-spectrum antibiotics (ABx) on EtOH-induced liver steatosis and injury. WT and IEhif1α−/− mice were fed 5% alcohol liquid diets for 24 days (n=4–6). Antibiotics treatment was started at day 12 after alcohol feeding, and mice were gavaged daily until harvesting. (A) Oil red O staining of hepatic tissues. Original magnification, ×10. (B) Quantification of hepatic triglyceride content. (C) Serum ALT levels. Data are mean ± SEM. AF, alcohol-fed; PF, pair-fed.