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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Hepatol. 2018 May 25;69(4):886–895. doi: 10.1016/j.jhep.2018.05.021

Figure 8.

Figure 8

Effects of Hif-1α on Lactobacillus rhamnosus GG treatment in ALD. Mice were fed alcohol following the NIAAA model (n=5 for each group). (A) HE staining revealed LGG administration reduced steatosis by alcohol exposure in WT mice. However, LGG protective effects were diminished in IEhif1α−/− mice. (B) Quantification of hepatic triglyceride content. (C,D) Serum ALT and AST levels. (E) Fecal butyrate concentration. (F) Ileum Claudin-1 and P-gp mRNA levels. Data are expressed as mean ± SEM. AF, alcohol-fed; PF, pair-fed.