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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 1.

Figure 1

Thermodynamic box for describing the equilibrium binding constant of the transition state as described by Pauling and formalized by Wolfenden. E and A are enzyme and reactant, kchem and kenz are the rates of transition state formation without and with enzyme, and Kd and Kd‡ are dissociation constants for the Michaelis and transition state complexes, respectively.