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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 13.

Figure 13

Distance map for the catalytic site of CfNH with contacts to the catalytic site and pAPIR as a catalytic site ligand. His82 is 3.6 Å from the leaving group and has been considered a potential leaving group proton donor. Note the 2.7 Å neighboring group interaction between O5′ and O4′. Reproduced from ref 96. Copyright 1996 American Chemical Society.