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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 26.

Figure 26

Comparison of electrostatic potentials for the transition state (a) of saporin L3 and the transition state mimic (b) of a truncated 2-base transition state mimic (c). This truncated inhibitor is a 3.3 nM TS analogue. Reproduced from ref 175. Copyright 2016 American Chemical Society.