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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 32.

Figure 32

Active site of Pf HGXPRT bound to the 0.65 nM inhibitor of Figure 29 and MgPPi. Hydrogen bonds are represented as dashed lines. All distances are in Angstroms. Two-dimensional representation of the active site where the ionic bond between pyrophosphate and the ribocation mimic is represented as a thick dashed line. Water molecules are represented as red dots, and the hydrophobic residues interacting with the purine ring are drawn in orange. Reproduced with permission from ref 189. Copyright 2012 Elsevier.