Figure 35.
Synthesis of the amidrazone 10, reported to be an inhibitor of yeast OPRT. (a) (BnO)2PO2H, DEAD, THF, 2 h, 25 °C; (b) Et3O+PF6–, CH2Cl2, 2 h, 25 °C; (c) o-hydrazinoPhCO2H, i-Pr2Net, CH2Cl2, 16 h, 25 °C; dil aq HCl; (d) 8 M HCl, 16 h, 25 °C. Reproduced with permission from ref 225. Copyright 2006 Elsevier.