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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 43.

Figure 43

Heat capacity changes and optimal binding temperatures for MTAP. (A) ΔCp for inhibitor binding. DADMe-ImmH binding to PNP (9 pM) is included as a control. (B) Free energy of inhibitor binding to MTAP as a function of temperature. Optimal binding temperature is the minima. DADMe-ImmH binding to PNP is added for comparison. Reproduced from ref 255. Copyright 2016 American Chemical Society.