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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 49.

Figure 49

Examples of transition state analogue affinity for E. coli, V. cholera, and H. pylori MTANs. These are slow-onset tight-binding inhibitors. Values are for the equilibrium binding dissociation constants following slow-onset inhibition.285 nd = not reported.