Skip to main content
. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 61.

Figure 61

Synthesis of the DADMe-Immucillins by the Mannich reaction.362 Conditions: (a) 30% aqueous formaldehyde, NaOAc, H2O, 95 °C. R1 = OH, SBn, SPhpCl, or OAc. R2 = OH or OAc. R3 = OH, NH2, Cl, or N3. R4 = H or NH2.