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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 65.

Figure 65

Reaction coordinate motion in bovine PNP based on the crystal structures with ImmH and phosphate bound (gray) compared to enzyme with hypoxanthine and ribose 1-phosphate bound (red).365