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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 67.

Figure 67

Isotope labels in ImmH (left) and DADMe-ImmH (right) to compare bond distortions at these bonds for inhibitors in solution or bound at the catalytic sites of human PNP. Blue arrows indicate atomic interactions for REDOR distance measurements, and blue brackets are for R2 homonuclear distance measurements. Reproduced with permission from ref 381. Copyright 2013 National Academy of Sciences.