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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 73.

Figure 73

Role of PNP deficiency in dGuo accumulation and T-cell toxicity. DNA recycling generates dGuo which accumulates in the absence of PNP activity. dGuo is phosphorylated in activated T cells by their elevated dCK activity. High levels of dGTP inhibit ribonucleotide diphosphate reductase (RDR). Activated T cells induce dCK and repress 5′-nucleotidases (5′-NT). Reproduced with permission from ref 395. Copyright 2001 National Academy of Sciences.