Skip to main content
. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 83.

Figure 83

Crystal structure of TvPNP with ImmA or DADMe-ImmA and PO4 bound in the active site. The asymmetric unit was used to generate the hexamer by applying 2-fold crystallographic symmetry (upper panel). Monomer pairs are represented with similar colors. (Lower panel) Superposition of the Immucillins at the active sites of the two TvPNP structures. The complex with ImmA is in pink, and the complex with DADMe-ImmA is in cyan. H4* is a catalytic site interaction from the adjacent subunit. Reproduced from ref 445. Copyright 2006 American Chemical Society.