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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Figure 87.

Figure 87

Clinically approved inhibitors for HIV-1 protease. Kd values and year of approval are indicated. The transition state center is highlighted. Adapted with permission from ref 459. Copyright 2017 Elsevier Paris.