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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Chem Rev. 2018 Oct 18;118(22):11194–11258. doi: 10.1021/acs.chemrev.8b00369

Table 2.

Symmetric and Asymmetric Acyclic Nucleoside Bisphosphonate Ki Value with Human and P. falciparum Purine PRTs198–20,1

No. Base Acyclic moiety Human HGXPRT Ki[μM] P. f. HGXPRT Ki[μM]
1a G graphic file with name nihms-1034037-t0090.jpg 0.03 0.07
1b Hx 1 5
2a G graphic file with name nihms-1034037-t0091.jpg 0.6 0.5
2b Hx 0.7 NIa
27 8-Br-G 0.4 0.9
20 G graphic file with name nihms-1034037-t0092.jpg 0.006 0.07
21 Hx 1.8 3
22 8-Br-G 0.1 2
23 8-Br-Hr 2.5 NI
24 7-deaza-G 0.1 4
25 7-deaza-Hx 4.6 6
a

No inhibition obseved. Base abbreviations are guanine (G), hypoxanthine (Hx), and 8-bromo (8-Br).