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. 2014 Sep 10;34(37):12368–12378. doi: 10.1523/JNEUROSCI.2102-14.2014

Figure 8.

Figure 8.

Peripherin immunoreactivity induced by 21–140 hfib αS 4 months after injection in M20 Tg mice and 2 months after injection in M83 Tg mice. Immunohistochemistry with anti-peripherin shows the expression of cytoplasmic peripherin in both M20 Tg mice (A) and M83 Tg mice (B). Aberrant expression of peripherin was not observed in M20 Tg mice at 4 months after injection of Δ71–82 αS (C) or away from the site of injection (in the entorhinal cortex) at 4 months after injection of 21–140 hfib αS (D). Immunofluorescence analysis of the hippocampus with anti-peripherin and anti-p62 or anti-pSer129/81A in M20 Tg mice 4 months after 21–140 hfib αS injection (E) or in M83 Tg mice 2 months after 21–140 hfib αS injection (F) shows that some cells containing p62 inclusions or pSer129 inclusion pathology also express peripherin; however, some neurons demonstrating peripherin immunoreactivity did not have these inclusions. Cell nuclei were stained with DAPI. Scale bars: 250 μm; insets, 62.5 μm.