Table 1.
Biophysical properties of WT and mutant Nav1.7 channels
| Nav1.7 | Current density |
Activation (mV) |
Steady-state fast inactivation (mV) |
Steady-state slow inactivation (mV) |
Closed-state inactivation (mV) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| pA/pF | n | V1/2,act | k | n | V1/2,fast | k | n | V½,slow | k | A% | n | V½,closed | k | n | |
| WT | −285 ± 41 | 28 | −24.0 ± 1.3 | 8.77 ± 0.40 | 24 | −84.2 ± 0.80 | 6.33 ± 0.15 | 19 | −65.6 ± 2.0 | 11.4 ± 0.68 | 10.7 ± 1.1 | 5 | −87.0 ± 0.70 | 6.26 ± 0.68 | 5 |
| R1279P | −237 ± 30 | 34 | −18.1 ± 0.78*** | 9.19 ± 0.23 | 32 | −74.6 ± 0.79*** | 6.82 ± 0.26 | 30 | −58.0 ± 2.4* | 11.6 ± 0.52 | 10.6 ± 1.6 | 6 | −78.6 ± 1.5*** | 6.99 ± 0.53 | 5 |
*p < 0.05 versus WT channels;
***p < 0.001 versus WT channels.