Figure 8.

Depolarization of PVCs with CCK8 facilitates optogenetically evoked SWRs after blockade of fast excitatory transmission. A, LFP recordings showing optogenetic stimulation (blue marks; 20 ms) of PV cells during the baseline period (top) and after blockade of AMPA and NMDA receptors (middle and bottom). Note that a selective tonic depolarization of PV cells with CCK8 (bottom; 500 nm; n = 4) assisted the optogenetic induction of SWR-like field potential transients in this experiment. B, C, Averages of evoked waveforms (60 events) before (B) and after (C) adding CCK8 to the bath solution.