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. 2014 Aug 20;34(34):11426–11438. doi: 10.1523/JNEUROSCI.0344-14.2014

Figure 1.

Figure 1.

Physiological distribution of triol. A, The fundamental metabolic pathway of cholesterol. Cholesterol is transformed into cholesterol-5,6-epoxide (5,6-epoxide) via oxidation and then is hydrated into triol by ChEH. B, The plasma concentrations of triol in rabbits and humans. All values represent mean ± SD of six individuals. C, LC–MS spectra of triol in the SIM mode with m/z of 384.7–385.7 in rat blood, brain, spinal cord (S.C.), liver, and kidney. IS indicates the internal standard (3β,6β-dihydroxyl-cholestane-24-one) in the SIM with m/z of 400.7–401.7 in rat liver. The APCI source and the positive ion mode were involved in the measurement. D, The distribution of triol in rats. All values represent mean ± SD of six rats.