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. 2019 May 16;14(8):804–817. doi: 10.1080/15592294.2019.1615358

Figure 2.

Figure 2.

The effect of FA on DNA methyltransferases in HepG2 cells. (a) RNA isolated from control and FA-treated HepG2 cells were reverse transcribed into cDNA and analyzed by qPCR. Fusaric acid significantly decreased the mRNA expression of DNMT1, DNMT3A, and DNMT3B in HepG2 cells. (b) Protein expression of DNMT1, DNMT3A, and DNMT3B were determined by Western blot. Fusaric acid decreased the protein expression of DNMT1, DNMT3A, and DNMT3B in HepG2 cells. Results are represented as mean fold-change ± SD (n = 3). Statistical significance was determined by one-way ANOVA with the Bonferroni multiple comparisons test (*p < 0.05, **p < 0.005, ***p < 0.0001).