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. 2019 May 16;14(8):804–817. doi: 10.1080/15592294.2019.1615358

Figure 6.

Figure 6.

The effect of FA on MBD2 promoter methylation and MBD2 expression in HepG2 cells. (a) DNA isolated from control and FA-treated HepG2 cells were assayed for MBD2 promoter methylation using the OneStep qMethyl Kit. Fusaric acid significantly induced promoter hypomethylation of MBD2 in HepG2 cells. (b) Protein expression of MBD2 was determined by Western blot. Fusaric acid significantly increased the protein expression of MBD2 in HepG2 cells. Results are represented as mean fold-change ± SD (n = 3). Statistical significance was determined by one-way ANOVA with the Bonferroni multiple comparisons test (***p < 0.0001).