Table 2.
RASSF1A methylation according to clinical, histopathological, and immunohistochemical markers in 75 invasive ductal breast carcinomas.
| Variables |
Methylation status |
||
|---|---|---|---|
| Methylated | Unmethylated | p-value | |
| Age (years) | |||
| ≤55 | 31 | 4 | 0.5276 |
| >55 | 33 | 7 | |
| Clinical stage* | |||
| I, IIA, IIB | 51 | 11 | 0.1930 |
| IIIA, IIIB | 12 | 0 | |
| Tumour size** | |||
| ≤20 mm | 14 | 4 | 0.4474 |
| >20 mm | 48 | 7 | |
| Histological grade | |||
| I, II | 35 | 6 | 1.0 |
| III | 29 | 5 | |
| Lymph nodes involvement* | |||
| ≤4 | 49 | 10 | 0.4430 |
| >4 | 14 | 1 | |
| Distant metastasis | |||
| Presence | 8 | 0 | 0.5950 |
| Absence | 56 | 11 | |
| p53*** | |||
| Negative | 43 | 8 | 0.999 |
| Positive | 16 | 3 | |
| Her-2 | |||
| Negative | 56 | 9 | 0.6145 |
| Positive | 7 | 2 | |
| ER* | |||
| Negative | 19 | 5 | 0.3207 |
| Positive | 44 | 6 | |
| PgR* | |||
| Negative | 33 | 6 | 0.9999 |
| Positive | 30 | 5 | |
| Ki-67 | |||
| Low (≤25%) | 40 | 6 | 0.7405 |
| High (>25%) | 24 | 5 | |
data available for (*)74, (**) 73, and (***) 70 breast cancer patients; p-value obtained by Fisher’s exact test.