Table 2.

Estimates of memory trajectories. All models include demographic variables (see text for details)

Variable¶	Model 1	Model 2	Model 3	Model 4
Time	−0.078±0.016**	−0.076±0.015***	−0.069±0.022**	−0.054±0.030
Gender (M)	−0.19±0.10	−0.11±0.10	−0.14±0.09	−0.11±0.09
Age	−0.02±0.02	−0.02±0.01	−0.02±0.01	−0.02±0.01
Education	0.06±0.03	0.07±0.03*	0.08±0.03**	0.07±0.03*
PET Image Time Lag	0.14±0.04**	0.09±0.04*	0.06±0.04	0.05±0.04
PiB Index	−0.88±0.37*	−0.69±0.35	−0.51±0.32	−0.63±0.33
PiB Index * Time	−0.21±0.07**	−0.19±0.07**	−0.20±0.07**	−0.20±0.07**
Hippocampus		411±143**	124±149	153±149
Hippocampus * Time		13.1±21	19.4±26	20.2±26
Impairment			−0.46±0.12***	−0.45±0.11***
Impairment * Time			0.011±0.02	0.013±0.02
Vascular Burden				−0.10±0.07
Vascular Burden * Time				−0.008±0.01

^¶Age centered at 70 years, male gender and education centered at 12 years was included in all models. Hippocampus and brain volume expressed as %TCV centered to non-impaired mean volume, WMH volume expressed as log WMH %TCV centered to non-impaired mean volume. PiB Index centered to non-impaired mean DVR. p values: <0.0005***, <0.005**, <0.05*. TCV, total cranial volume; WMH, white matter hyperintensities; PiB, Pittsburg Imaging Compound B.