Table 3.

Estimates of executive function trajectories

Variable¶	Model 1	Model 2	Model 3	Model 4
Time	−0.036±0.013**	−0.030±0.011*	−0.046±0.016**	−0.07±0.02*
Gender (M)	−0.10±0.06	−0.07±0.07	−0.08±0.06	−0.05±0.06
Age	−0.02±0.01*	−0.02±0.01*	−0.02±0.01*	−0.02±0.01
Education	0.10±0.02***	0.10±0.02***	0.10±0.02***	0.10±0.02***
PET Imaging Time Lag	0.07±0.03**	0.05±0.03	0.05±0.03	0.03±0.03
PiB Index	0.21±0.23	0.25±0.24	0.29±0.23	0.13±0.23
PiB Index * Time	−0.20±0.05***	−0.16±0.05**	−0.14±0.05**	−0.14±0.05*
Hippocampus		105±95	26.2±108	65±104
Hippocampus * Time		46±15.6*	31.1±17.7	28.8±19.1
Impairment			−0.12±0.09	−0.10±0.08
Impairment * Time			−0.03±0.02	−0.03±0.02
Vascular Burden				−0.14±0.05**
Vascular Burden * Time				0.011±0.01

^¶Age centered at 70 years, male gender and education centered at 12 years was included in all models. Hippocampus and brain volume expressed as %TCV centered to non-impaired mean volume, WMH volume expressed as log WMH %TCV centered to non-impaired mean volume. PiB Index centered to non-impaired mean DVR. p values: <0.0005***, <0.005**, <0.05*. TCV, total cranial volume; WMH, white matter hyperintensities; PiB, Pittsburg Imaging Compound B.