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. Author manuscript; available in PMC: 2019 Dec 21.
Published in final edited form as: Adv Synth Catal. 2018 Sep 30;360(24):4705–4709. doi: 10.1002/adsc.201800876

Scheme 2.

Scheme 2.

Substrate scope of the cyanomethylation of trifluorome-thyl ketones. Reaction conditions: All reactions were performed with trifluoromethyl ketone 1 (0.3 mmol), cyanoacetic acid 2 (0.6 mmol) and triethylamine (0.06 mmol) in 1 mL of THF at 60 °C. See SI for details.