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. 2019 Jul 9;14(7):e0219256. doi: 10.1371/journal.pone.0219256

Fig 2. Epitope mapping.

Fig 2

For representative mAbs, epitope mapping data are shown. (A) Binding for each mAb was quantified against a panel of 26 15-mer peptides (overlap of 3 residues) spanning the sequence of the S. aureus HU. TRL1335 is a weak binding control with no well defined epitope. (B) The lead clinical candidate and backup mAbs, TRL1068 and TRL1330, bind to the most highly conserved region. Yellow highlighting indicates identity over all strains; blue highlighting indicates partial identity; green highlighting indicates conservative substitution.