Fig 4. Comparison of mutations observed in vitro and in vivo.

Description of non-synonymous mutations observed during in vitro and in vivo experiments. For the list of isolates in which the same mutations was observed in natura, the name of the lineage is indicated in bold according to the previous defined nomenclature [7]. Mutations highlighted in red boxes are those observed during experimental passages in foxes but never in dogs or in dog-RABV in natura. Mutations in bold are those observed in the last passage of each type of passages. Mutations highlighted in grey are observed in a large set of sequences observed in the 3 categories of host species. The following code has been used to describe the mutations: P-H38Q denotes a mutation from H to Q in position 38 of the phosphoprote.