Fig 2. Reduced viremia and virus titers in a variety of organs of TIM-1^-/- mice at late time points following i.v. EBOV GP ΔO/rVSV infection.

Serum and organs were harvested from BALB/c Ifnar ^-/- (Control) and BALB/c Ifnar ^-/-/TIM-1^-/- (TIM-1^-/-) mice at days 1, 3 and 5 following infection with 10⁵ iu of EBOV GP ΔO /rVSV by i.v. injection. Titers were determined by endpoint dilution of serum or homogenized organ samples on Vero cells. Solid lines indicate geometric mean for each data set. Dotted line indicates the level of detection. Adrenal gland titers are displayed as per gland homogenized in 1 ml of PBS. Significance was calculated by Mann-Whitney test to compare control to TIM-1^-/- mice at each time point; *p < 0.05; **p < 0.01; ns, not significant.