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Summary of biophysical characteristics of the species of α-synuclein used in this study
NA means not applicable.
| Species | Average length | Secondary structure | Configuration | Amyloid | Seeding-competent |
|---|---|---|---|---|---|
| nm | |||||
| Monomer | NA | Random coil | NA | No | No |
| Fibrils | 266 | 60% β-sheet | Parallel | Yes | Yes |
| Fragmented fibrils (mix, “F-M”) | 120 | 60% β-sheet | Parallel | Yes | Yes |
| Fragmented fibrils (short, “F-S”) | 70 | 60% β-sheet | Parallel | Yes | Yes |
| Oligomers (“O”) | 54 | 30% β-sheet | Anti-parallel | No | No |
