Table 2.
Associations of bio-ADM and congestion
| Univariable model | HARVEST-Malmö | GREAT Network Rome | Pooled cohort | ||||||
| N; events | OR (95% CI) | P value | N; events | OR (95% CI) | P value | N; events | OR (95% CI) | P value | |
| Peripheral oedema | 276; 200 | 2.93 (2.04 to 4.21) | <0.001 | 192; 116 | 1.71 (1.24 to 2.36) | <0.001 | 486; 322 | 2.22 (1.76 to 2.80) | <0.001 |
| Persistent dyspnoea | 295; 272 | 1.03 (0.67 to 0.58) | 0.888 | 191; 177 | 0.76 (0.46 to 1.23) | 0.302 | 486; 449 | 0.90 (0.64 to 1.24) | 0.507 |
| Congestion on X-ray | 274; 239 | 0.98 (0.69 to 1.39) | 0.914 | 188; 169 | 1.11 (0.68 to 1.79) | 0.677 | 462; 408 | 0.99 (0.75 to 1.33) | 0.997 |
| Rales | 291; 209 | 0.96 (0.75 to 1.23) | 0.746 | 192; 160 | 1.09 (0.74 to 1.61) | 0.650 | 483; 364 | 0.93 (0.76 to 1.15) | 0.498 |
| Severe congestion | 253; 122 | 1.59 (1.22 to 2.06) | <0.001 | 187; 76 | 1.30 (0.97 to 1.75) | 0.077 | 440; 198 | 1.47 (1.21 to 1.78) | <0.001 |
| Model 1 | |||||||||
| Peripheral oedema | 276; 200 | 3.12 (2.14 to 4.56) | <0.001 | 192; 116 | 1.69 (1.22 to 2.35) | 0.002 | 486; 322 | 2.29 (1.81 to 2.91) | <0.001 |
| Persistent dyspnoea | 295; 272 | 1.04 (0.68 to 1.59) | 0.852 | 191; 177 | 0.72 (0.42 to 1.21) | 0.213 | 486; 449 | 0.92 (0.66 to 1.29) | 0.239 |
| Congestion on X-ray | 274; 239 | 0.97 (0.68 to 1.38) | 0.967 | 188; 169 | 1.12 (0.69 to 1.82) | 0.653 | 462; 408 | 0.98 (0.73 to 1.29) | 0.867 |
| Rales | 291; 209 | 0.96 (0.75 to 1.24) | 0.780 | 192; 160 | 1.11 (0.75 to 1.64) | 0.598 | 483; 364 | 0.96 (0.78 to 1.19) | 0.722 |
| Severe congestion | 253; 122 | 1.65 (1.26 to 2.17) | <0.001 | 187; 76 | 1.27 (0.94 to 1.71) | 0.115 | 440; 198 | 1.48 (1.21 to 1.80) | <0.001 |
| Model 2 | |||||||||
| Peripheral oedema | 276; 200 | 3.01 (2.02 to 4.47) | <0.001 | 192; 116 | 1.79 (1.26 to 2.54) | 0.001 | 486; 322 | 2.30 (1.29 to 2.97) | <0.001 |
| Persistent dyspnoea | 295; 272 | 0.97 (0.61 to 1.55) | 0.903 | 191; 177 | 0.79 (0.45 to 1.39) | 0.451 | 486; 449 | 0.95 (0.66 to 1.36) | 0.948 |
| Congestion on X-ray | 274; 239 | 0.93 (0.65 to 1.34) | 0.702 | 188; 169 | 0.99 (0.58 to 1.69) | 0.973 | 462; 408 | 0.90 (0.67 to 1.22) | 0.491 |
| Rales | 291; 209 | 0.94 (0.71 to 1.25) | 0.680 | 192; 160 | 1.18 (0.78 to 1.80) | 0.436 | 483; 364 | 0.98 (0.78 to 1.24) | 0.884 |
| Severe congestion | 253; 122 | 1.58 (1.18 to 2.11) | <0.002 | 187; 76 | 1.33 (0.97 to 1.82) | 0.079 | 440; 198 | 1.46 (1.18 to 1.80) | <0.001 |
Values are OR with 95% CI for associations of bio-ADM and each sign of congestion, as well as bio-ADM and severe congestion (highest values on the congestion score (CCS=4). Model 1 is age and sex adjusted. Model 2 is further adjusted for systolic blood pressure, log-transformed and normalised B-type natriuretic peptide, prevalent atrial fibrillation and prior heart failure.
CCS, clinical congestion score; HARVEST, HeArt and bRain failure inVESTigation trial; bio-ADM, bioactive adrenomedullin.