Table 4.

Logistic regression model for in-hospital mortality for bio-ADM and penKid

	Univariable			Bivariable: BioADM			Bivariable: PenKid
	OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
Age	1.04	0.99 to 1.09	0.067	1.54	1.03 to 2.31	0.037	2.16	1.49 to 3.13	<0.001
Sex	0.53	0.24 to 1.16	0.112	1.58	1.05 to 2.37	0.028	2.19	1.53 to 3.14	<0.001
Diabetes	0.85	0.37 to 1.92	0.689	1.52	1.01 to 2.28	0.045	2.23	1.56 to 3.19	<0.001
SBP	0.99	0.98 to 1.01	0.254	1.48	0.98 to 2.25	0.063	2.28	1.59 to 3.27	<0.001
ACE-i	0.60	0.26 to 1.36	0.217	1.49	0.99 to 2.23	0.056	2.24	1.56 to 3.21	<0.001
ARB	0.92	0.46 to 1.81	0.798	1.51	1.01 to 2.27	0.049	2.27	1.58 to 3.25	<0.001
Betablockers	0.20	0.09 to 0.46	<0.001	1.61	1.08 to 2.40	0.020	2.08	1.44 to 3.00	<0.001
Prior HF	0.54	0.25 to 1.19	0.127	1.63	1.09 to 2.46	0.018	2.22	1.56 to 3.15	<0.001
Creatinine	1.77	1.27 to 2.46	0.001	1.38	0.90 to 2.11	0.139	2.31	1.51 to 3.53	<0.001
BNP	1.28	0.85 to 1.92	0.235	1.42	0.93 to 2.15	0.105	2.29	1.56 to 3.35	<0.001
Smoking	0.43	0.10 to 1.84	0.255	1.47	0.97 to 2.21	0.067	2.25	1.57 to 3.23	<0.001
Prevalent AF	0.47	0.20 to 1.09	0.078	1.50	1.01 to 2.25	0.047	2.18	1.53 to 3.11	<0.001
Bio-ADM	1.50	1.00 to 2.26	0.051				2.19	1.52 to 3.15	<0.001
penKid	2.24	1.57 to 3.20	<0.001	1.34	0.88 to 2.03	0.168

Values are OR with 95% CI. All results are reported for the pooled cohort (n=470, 24 events). Univariable results are presented as each variable’s associations with in-hospital mortality. Bivariable results are reported for penKid and bio-ADM, adjusted for each variable separately.

ACE-I, ACE inhibitors; AF, atrial fibrillation; ARB, angiotensin receptor blocker; BNP, B-type natriuretic peptide; Bio-ADM, bioactive adrenomedullin; HF, heart failure; SBP, systolic blood pressure; penKid, proenkephalin A 119–159.