Figure 6. Apolipoprotein E (APOE) ε4 alleles negatively influence PAL performance in the presence of FH.
(A) Linear regression fits (line fill ±95% CI, error bars ± SEM) of the PAL total number of correct from 18 to 65 years old. Lines were split by the Number of APOE ε4 Alleles. For women and men, there was a dose-dependent-like decrease in the PAL scores per each copy of the ε4 allele (Bε4Allele = −1.30, pε4Allele = 0.03, ε2/ε2 n = 2, ε2/ε3 n = 31, ε2/ε4 n = 46, ε3/ε3 n = 174, ε3/ε4 n = 382, and ε4/ε4 n = 35).