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. 2019 Jun 14;55(2):391–404. doi: 10.3892/ijo.2019.4825

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Copyright: © Owusu-Ansah et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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COL6A1 expression affects the prognosis of patients with pancreatic cancer. (A) Data from the GEPIA database indicated that patients with high COL6A1 expression levels exhibited significantly decreased survival compared with those with low COL6A1 expression (P=0.017 and 0.016). (B) A representative diagram of TMA organization (left); cancer tissue and paracancerous tissue are represented as blue and green, respectively. Overview of TMA slide (right) of stained by IHC with COL6A1 antibody. (C) Representative images of immunohistochemically stained paracancerous and cancer tissues. Scale bar, 100 μm. Magnification of insert, x40. (D) COL6A1⁺ rate was significantly higher in cancerous tissue compared with paracancerous tissue (P=0.001). (E) Kaplan-Meier survival plot of patient specimens indicate that patients with COL6A1⁺ expression in tumor tissues showed significantly decreased survival compared with patients possessing COL6A1⁻ expression (P=0.001). Data were analyzed using IBM SPSS v25. CA, cancer; COL6A1, collagen type VI α1 chain; HR, hazard ratio; PCa, paracancerous; TMA, tissue microarray.