Table I.
IPA analysis of statistically significant upregulated and downregulated pathways in T24 SOX4-KD cell lines compared to T24-SOX4-Rescue cell lines.
| ↓ or ↑ | P-value | Ingenuity canonical pathways |
|---|---|---|
| – | 2.29E-06 | Axonal guidance signaling |
| – | 1.78E-04 | Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis |
| – | 4.07E-04 | Human embryonic stem cell pluripotency |
| ↓ | 1.41E-03 | Basal cell carcinoma signaling |
| ↓ | 1.45E-03 | Colorectal cancer metastasis signaling |
| – | 1.78E-03 | Role of Wnt/GSK-3 beta signaling in the pathogenesis of influenza |
| – | 2.24E-03 | Inhibition of matrix metalloproteases |
| – | 2.88E-03 | Ovarian cancer signaling |
| ↑ | 3.09E-03 | Osteoarthritis pathway |
| ↓ | 6.17E-03 | Wnt/β-catenin signaling |
| – | 7.94E-03 | PCP pathway |
| – | 8.71E-03 | Wnt/Ca2+ pathway |
| – | 8.91E-03 | Regulation of the epithelial-mesenchymal transition pathway |
| – | 9.12E-03 | Role of NANOG in mammalian embryonic stem cell pluripotency |
↓ or ↑ indicate down- or upregulation, respectively.