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. 2019 Jul 2;55(2):347–358. doi: 10.3892/ijo.2019.4835

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Copyright: © Maurer et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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AML cells can be targeted by a combination of MeV-SCD and 5-FC. (A-C) MM-6 cells or (D-G) the PBMC fraction from a patient with AML (UPN 2) were infected with MeV-SCD or MOCK-infected. Cells were analyzed at 4 dpi. (A and E) Cell number was determined using the Countess Automated Cell Counter. The percentage of living cells is indicated (MM-6 and UPN 2, n=2 each). (B and F) Viability of cells was measured using CellTiter-Blue viability assay. MM-6 (n=2); UPN 2 (n=1). (C and G) Apoptosis was determined by staining with TMRE and subsequent FACS analysis. The percentage of TMRE-negative cells is indicated. MM-6 (n=2); UPN 2 (n=1). (D) The percentage of leukemic blasts is displayed. (A-C and E-G) Values depict means of data from the indicated number of independent experiments. AML, acute myeloid leukemia; MeV, measles vaccine virus; PBMC, peripheral blood mononuclear cell; UPN, unique patient number.