Table I.
Prognostic signatures based on each type of splicing event.
| Type of splicing event | Algorithm | HR (95% CI) | ROC curve |
|---|---|---|---|
| Alternate acceptor sites (AA) | 'SWI5-87732-AA' * 0.03740 + 'FDPS-8074-AA' * 0.02940 + 'COMT-61101-AA' * 0.31109 | 2.334 (1.644-3.314) | 0.743 |
| Alternate donor sites (AD) | 'VPS28-85610-AD' * 1.70e-01 + 'UBE2D3-70148-AD' * (−1.57e-02) + 'TXNDC17-38768-AD' * 9.27e-02 + 'TPT1-25803-AD' * 1.62e+01 + 'SUMF2-79789-AD' * 3.92e-02 + 'SMIM19-83740-AD' * 2.69e-02 + 'RPL26-39180-AD' * 6.06e-01 + 'NDUFB11-88904-AD' * 4.87e-02 + 'IRF3-50997-AD' * (−8.62e-03) + 'F10-26354-AD' * 2.21e-02 + 'CCDC90B-18085-AD' * 2.02e-02 + 'C1orf159-13-AD' * (−1.12e-02) + 'ADCK4-49949-AD' (-4.56e-02) | 2.423 (1.700-3.455) | 0.718 |
| Alternate promoters (AP) | 'RPL27-41172-AP' * 0.21696 + 'RCL1-85779-AP' * −0.00550 + 'NUDT6-70523-AP' * 0.01129 + 'MXI1-13080-AP' * 0.00857 + 'DUSP22-75126-AP' * 0.07876 + 'CYB5A-45803-AP' * 0.49517 + 'CHPF-57719-AP' * 0.07805 | 2.687 (1.891-3.818) | 0.728 |
| Alternate terminators (AT) | 'ZSCAN20-1679-AT' * 0.01077 + 'ZNF706-84737-AT' * 0.06539 +'WWOX-37672-AT' * −0.03181 + 'NUCB2-14523-AT' * −0.07215 +'NEIL3-71227-AT' * 0.01306 + 'MORN1-252-AT' * 0.00837 + 'FRMD4A-10810-AT' * 4.59555 + 'CRISPLD2-37867-AT' * 0.24507 + 'ACAT1-18599-AT' * 0.69847 | 2.850 (2.001-4.057) | 0.709 |
| Exon skips (ES) | 'USF2-49098-ES' * 0.03030 + 'TRAPPC6A-50409-ES' −0.03711 + 'TMEM150A-54305-ES' −0.01822 + 'TMEM120B-24894-ES' * 0.00897 + 'TCF3-46542-ES' * −0.02326 + 'SSR4-90499-ES' * 0.95791 + 'SMIM7-48191-ES' * 0.26393 + 'SHBG-39015-ES' * −0.02339 'PTRH1-87649-ES' * −0.64609 + 'PPP6R2-62825-ES' * −0.03581 + 'PPP2CB-83304-ES' * −3.17592 + 'PGAP3-40670-ES' * 0.06043 + 'PCYT2-44234-ES' * 0.12079 + 'OCEL1-48244-ES' * −0.04796 + 'SOC2-52105-ES' * 0.01667 + 'IRF3-50995-ES' * −0.03249 + 'IRF3-50990-ES' * 0.04115 + 'FKBP8-48448-ES' * −0.71033 + 'ECHDC2-3037-ES' * 0.04796 + 'CYTH1-43890-ES' * 0.01764 + 'CHRD-67959-ES' * −0.01020 + 'C16orf13-32924-ES' * 0.03301 + 'C14orf2-29536-ES' * 0.38460 + 'BAX-50838-ES' * −0.35118 + 'ARHGEF10L-862-ES' * 0.01344 + 'AFMID-94694-ES' * −0.01010 + 'ACAA1-64027-ES' * −0.71363 | 4.938 (3.439-7.090) | 0.898 |
| Mutually exclusive exons (ME) | 'SLC39A14-140283-ME' * (−0.00563) + 'H2AFY-96931-ME' * 0.02881 | 1.878 (1.320-2.672) | 0.641 |
| Retained introns (RI) | 'RPL13-38091-RI' * 0.62076 + 'ROMO1-59223-RI` * 0.07039 + 'NUDT22-16590-RI' * 0.01621 + 'NAA60-33527-RI' * (−0.00942) + 'MRPL52-26642-RI' * 0.01287 + 'MDK-15571-RI' * 0.09757 + 'MARVELD2-72372-RI' * (−2.62393) | 2.895 (2.043-4.102) | 0.745 |
HR, hazard ratio; CI, confidence interval; ROC, receiver operating characteristic.