Table II.
Univariate and multivariate analyses of OS in HCC patients from TCGA by Cox regression analysis.
| Univariate analysis
|
Multivariate analysis
|
|||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (≥60/<60 years) | 1.212 (0.854-1.720) | 0.281 | ||
| Sex (male/female) | 0.817 (0.573-1.164) | 0.262 | ||
| Pathological stage (III-IV/I-II) | 2.446 (1.687-3.545) | <0.001 | 1.018 (0.138-7.527) | 0.986 |
| T stage (T3-T4/T1-T2) | 2.537 (1.783-3.609) | <0.001 | 1.757 (0.238-12.981) | 0.581 |
| Lymph node metastasis (yes/no) | 1.999 (0.490-8.161) | 0.334 | ||
| Distant metastasis (yes/no) | 4.033 (1.267-12.834) | 0.018 | 0.755 (0.179-3.177) | 0.701 |
| Histological grade (G3-G4/G1-G2) | 1.119 (0.780-1.604) | 0.542 | ||
| Tumor status during follow-up (tumor/tumor-free) | 2.366 (1.623-3.447) | <0.001 | 1.567 (0.979-2.508) | 0.061 |
| Vascular invasion (micro+macro/none) | 1.351 (0.892-2.047) | 0.155 | ||
| Relative family cancer history (yes/no) | 1.181 (0.818-1.704) | 0.375 | ||
| Prognostic index (high/low) | 12.904 (7.513-22.161) | <0.001 | 16.541 (7.660-35.717) | <0.001 |
OS, overall survival; HCC, hepatocellular carcinoma; TCGA, The Cancer Genome Atlas; HR, hazard ratio; CI, confidence interval.